Chondroitin Sulfate InteractionsMost herbs and supplements have not been thoroughly tested for interactions with other herbs, supplements, drugs or food. The interactions listed below are based on reports in scientific publications, laboratory experiments or traditional use. Always read product labels. If you have a medical condition or are taking other drugs, herbs or supplements, you should consult with a qualified healthcare provider before starting a new therapy.

Interactions with Drugs

In theory, chondroitin may increase the risk of bleeding when taken with drugs that increase the risk of bleeding. Some examples include aspirin, anticoagulants (“blood thinners”) such as warfarin (Coumadin ®) or heparin-platelet drugs such as clopidogrel (Plavix ®), and non-steroidal drugs anti-inflammatory such as ibuprofen (Motrin ®, Advil ®) or naproxen (Naprosyn ®, Aleve ®).

Use cautiously with hyaluronidase or agents with hydrophilic properties (attracted to water). Consult a health professional, including a pharmacist, to check for interactions.

Also be used with caution when combined with other agents that can cause sensitivity to sunlight and that chondroitin may increase sensitivity to sunlight.

Interactions with Herbs and Dietary Supplements

In theory, chondroitin may increase the risk of bleeding when taken with herbs or supplements that are believed to increase the risk of bleeding. Multiple cases of bleeding have been reported with the use of Ginkgo biloba, and fewer cases with saw palmetto. Numerous other agents may theoretically increase the risk of bleeding, although this has not been proven in most cases.

Based on preliminary data, chondroitin may increase iron absorption, may also interact or alter the concentrations of calcium, camphor, glucosamine, manganese, peppermint oil and shark cartilage.
Use cautiously with herbs or supplements with hydrophilic properties (attracted to water). Consult a health professional, including a pharmacist, to check for interactions. Also be used with caution when combined with other agents that can cause sensitivity to sunlight and that chondroitin may increase sensitivity to sunlight.

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